I have an Mbox 2 running into Parallels 3.0. I use it to edit in Adobe Audition and ever since using Parallels (year or so now) the audio will click/pop before and after playing audio. This occurs whether playing in Adobe Audition or with Windows Media Player. It's not the quality of the audio, this happens regardless of how clean the audio clips are. And while I'm on the subject the audio that is recorded (Audition) is never able to get any louder than a certain peak level that is well below where it should be. If I turn the input up on the Mbox or turn the input up on the soundboard it will just clip/distort.