When using this key combination, mouse wheeling is ignored. Setting Optimize Modifier Keys for Games makes no difference. It affects every application I attempted to use the mouse wheel in. Using the trackpad to scroll seems to work. 15" 2012 RMBP Mountain Lion 10.8.2 supplemental update 2 Windows 7 Ultimate 64-bit Logitech m100 mouse, connected to host OS. Parallels 8.0.18345