If you are using the 2X ApplicationServer Client from a 10.10.x.x network, it will get the list of published apps, but it will not ever connect to the terminal server. The full RDP desktop works fine.
After having this issue appear at 3 client's sites, I set up a firewall in the office and assigned the internal network to 10.10.1.0/24, and I was unable to connect to the terminal server via 2X. I changed the network to 10.11.1.0/24 and it worked fine. I also tried 10.10.0.0/16 with the same results. After further testing, I determined that any netowrk starting with 10.10 produces the same results, regardless of the subnet or last two octets.