I'm using Parallels 7.0.14922 (9/13/2011) on my 2011 MacBook Air 11" (10.7.2 11C71), running Windows 7 x64 Ultimate. The Parallels app will stop responding to mouse-click events on the Mac OS (and guest OS, Windows in this case) side. I am unsure what causes this, as the timing has been random and I have not been able to reproduce a set of actions that can cause it to occur. I typically am coding in Visual Studio 2011 SP1 under Parallels and I'll go to use the mouse and notice that I cannot click things anymore under Windows. The Parallels menus also do not work (like exiting Coherence mode through the dock icon menu). I cannot even force-quit the application since there is no application window in coherence mode. Mac OS itself seems to be unaffected otherwise. The strange part is that keyboard events work fine still. I can press Command, which shows the Windows start menu. From there I can launch applications and whatnot using the keyboard. At this point, I typically run the "shutdown -s -t 0" command so I can shut down Windows immediately without using a mouse. Once the VM is shut down, I can close and relaunch the Parallels application, restart the VM, and everything is fine -- until it decides to occur again. Kind of annoying, but I haven't had this bug until recently (last week). I've been running the 10.7.2 betas as they release, so I don't think it's just that. My 2011 27" iMac running the same 10.7.2 build does not have this issue. Using a USB mouse vs the built-in trackpad does not make a difference.