I was able to synchronize my Navman N40i GPS device with the supplied Windows-based SmartST Desktop software via the USB port on my MacBook Pro 17" Intel Core Duo 2.16 GHz 2GB RAM. The Point Of Interest (POI) Editor also worked fine. I was also able to import personalized POI data and to install new audio alert sound (WAV) files. Some Technical Details: Operating System: Mac OS X 10.4.8 (8L2127) Parallels Desktop for Mac Build 1970 Guest OS: Windows XP Professional Version 2002, Service Pack 2 Applications: Microsoft Active Sync version 4.2.0 (Build 4876), SmartST Desktop 2006 SE (v4.0.10.24)