Summary Parallels Desktop 5 for Mac will not start. The application will bounce in the dock for about a minute until finally settling down, but will never become operational. It will retain the Application Not Responding status in activity monitor until forcefully killed. System MacBookPro3,1 Mac OS X 10.6.1 Configuration This is a clean Parallels Desktop installation from the trial image available for download on the Web site. The exact image retrieved is ParallelsDesktop-parallels-en_US-5.0.9220.531002.dmg. VMWare Fusion 3 is installed and works properly. I attempted uninstalling, but the uninstaller will hang while trying to unregister the dispatcher. After 5 minutes a force quit was the only resolution. I thus performed a manual uninstallation following the instructions here: http://kb.parallels.com/en/4709. I then re-downloaded the installation image and tried again but to no avail. I uninstalled again. Interestingly, there were no kernel extensions similar to the ones in the KB during both uninstalls (although I did not run the uninstaller the second time). See the attached file for the parallels log.