Universal Printer-Print job does not open remote PDF application

We have recently seen issues with Universal printing where the print spooler clears just fine from the server but nothing comes up for the local print job. Running on Windows Server 2008 R2 64bit and Remote Application Server v16.2 Build 19048
We have no consistency when it happens or what the fix is. Sometimes its logging off all sessions and restarting the 2x client. Sometimes you can log into a full desktop and print then it works for a while and sometimes it just doesn't work at all. Most users are using Bluebeam for their default PDF viewer. Seems to be a issue with all of our published apps but predominately SAGE Timberline 300. Were getting to the point of moving to another solution.