From what I have seen.
The only real difference I have seen over fairly high bandwidth and low latency lines is the use of Encrypted or Non-Encrypted traffic. Using SSL as the connection produces some delay in typing speed and overall response time.
On lower bandwith with higher latency (56k-384k), you will have to look at colors, sound and drive mapping options. Using SSL as the connection will also effect this, but not as noticably since there will be some delay due to the lower bandwidth connection.
If a non-encrypted transport is not needed for say internal use, then I would say, do not use it. It will keep your users happier.
Rob