Can't click on windows in Coherence

JoeC1

Bit poster
I'm currently running on a Macbook Pro 15" (mid 2014) with 8 monitors (the retina display, 2 via DisplayPort, 1 via HDMI, and 4 via 2 DisplayLink hubs.)
The guest OS is Windows Server 2012 R2.
When running in Coherence mode, at random, none of the windows respond to mouse clicks. Alt+tab and other keyboard events still work against the windows, but clicking on any of the windows causes them to lose focus. If I switch out of coherence and back into windowed mode, it works fine. Also, switching to full screen across all 8 monitors works fine. It generally takes a full reboot of both the host and guest to resolve the issues with Coherence.
What's going on?
 
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