I loaded MapSource City Select North America v7 a few days ago with virtually no problems. I have successfully downloaded waypoints and tracks and saved the documents for both my Garmin eTrex Summit and GPS V. I have not yet uploaded maps or waypoints but expect to do so soon. Also, I have not yet done live GPS tracking. Soon I expect to load the software for my wife's C320 and give it a test run.
I am using a MacBook with 1 GB of RAM, Parallels Desktop Build 3188 and Windows XP Home. I bought the boxed version a few weeks ago and quickly upgraded to 3188 with no problems other than my own lack of knowledge. I use a KeySpan USA-19HS USB Serial Adapter. It worked the first time for both GPS receivers. The only nuisance I experience is occasionally having to unplug and reinsert the USB connector.
I do admit to reading a lot of threads on subjects like GPS and USB. I also admit to a lot of false starts that forced me to read more and experiment until I got it right. I am a new user of Parallels so have had to climb up the learning curve quickly. I bought Parallels specifically to use mapping software that is readily available for Windows. I successfully loaded Microsoft Streets & Trips and use it regularly.
The bottom line is that Parallels works for me and so far has met my expectations. It allowed me to return to the Mac platform after six years and bring some Windows applications with me. (My first Mac was a 512k and I still have Version 1.05 of Excel.)