I ran into the same problem on my upgrade to 16.04 from 15.10. I recalled that during the upgrade, there was a prompt regarding UEFI Secure Boot options. I checked my BIOS settings and sure enough, Discord Secure Boot was set to "Windows Only". Adobe Reader I selected "Other OS" from the list (your options may be different) and booted normally. All fixed iTunes.
Have not seen any other mentions of this fix so hopefully this will help.
Last edited: Aug 26, 2018